无催化剂条件下微波辐射一步法合成2-氨基-4-芳基-5-氧代-5,6,7,8-四氢-4H-苯并吡喃-3-腈有机化学.pdfVIP

2011 年第 31 卷 有 机 化 学 Vol. 31, 2011 第 6 期, 860～864 Chinese Journal of Organic Chemistry No. 6, 860～864 ·研究简报· 无催化剂条件下微波辐射一步法合成 2-氨基-4-芳基-5-氧代-5,6,7,8- 四氢-4H-苯并吡喃-3-腈 栾长军 a 王建强 a 张国华 a 王 伟 a 唐拾贵 b 郭 成*,a (a 南京工业大学理学院 南京 210009) (b 南京工业大学生物与制药工程学院 南京 210009) 摘要 以芳醛、丙二腈、1,3-环己二酮为原料在无催化剂条件下, 分别用微波辐射和传统加热法合成了一系列 2-氨基-4- 芳基-5-氧代-5,6,7,8- 四氢-4H-苯并吡喃-3-腈(4a～4g)衍生物. 与常规加热方法相比, 微波辐射法具有反应时间短、产率 高、后处理方便、环境友好等优点, 所有化合物均经 IR,1H NMR 和元素分析确定. 关键词 芳醛; 丙二腈; 1,3-环己二酮; 苯并吡喃; 微波 One-Pot Synthesis of 2-Amino-4-aryl-5-oxo-5,6,7,8-tetrahydro-4H- benzopyran-3-carbonitrile under Microwave Irradiation without Catalyst Luan, Changjuna Wang, Jianqianga Zhang, Guohuaa Wang, Weia Tang, Shiguib Guo, Cheng*,a (a College of Science, Nanjing University of Technology, Nanjing 210009) (b Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009) Abstract A series of 2-amino-4-aryl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile derivatives (4a～4g) were prepared by using 1,3-cyclohexanedione, aromatic aldehydes and malononitrile in anhydrous alcohol under microwave irradiation without catalyst. Compared with conventional heating method, the method of microwave irradiation possesses advantages including short time, high yield and environmental 1 friendliness, etc. The st