环状脱氢氨基酸及其衍生物的不对称催化氢化研究有机化学.pdfVIP

DOI: 10.6023/cjoc201502017 综述与进展 有机化学 Chinese Journal of Organic Chemistry REVIEW 环状脱氢氨基酸及其衍生物的不对称催化氢化研究 王英杰a 张振锋*,b 张万斌*,a,b (a 上海交通大学化学化工学院 上海 200240) (b 上海交通大学药学院 上海 200240) 摘要 手性环状氨基酸具有独特的结构和特殊的性能, 是广泛存在于手性药物和手性催化剂中的一种结构单元. 过渡 金属催化的不对称氢化具有高效、绿色和经济的优点而成为合成该类化合物的首选方法. 对该领域进行了综述, 介绍 了各种类型环状 α-和β-脱氢氨基酸及其衍生物的不对称催化氢化研究现状, 分析了各种类型钌(Ru)、铑(Rh)和铱(Ir)催 化剂的优势和不足, 并提出了该领域今后的研究重点和发展方向. 关键词 环状氨基酸; 环状脱氢氨基酸; 不对称氢化; 钌催化; 铑催化; 铱催化 Asymmetric Hydrogenation of Cyclic Dehydroamino Acids and Their Derivatives Wang, Yingjiea Zhang, Zhenfeng*,b Zhang, Wanbin*,a,b a ( School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240) b ( School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240) Abstract Chiral cyclic amino acids, possessing the unique structure and special properties, can be found in various chiral drugs and chiral catalysts as structural motifs. Transition-metal-catalyzed asymmetric hydrogenation, which has the advantages of high efficiency, environmental friendliness and atom economy, becomes the preferred method for the syntheses of such compounds. The related works on this field are reviewed for the first time in this paper. The catalytic asymmetric hydrogena- tion of various types of cyclic α