Localisation of Human Papillomavirus 16 E7 Oncoprotein Changes with Cell Confluence.PDFVIP

Localisation of Human Papillomavirus 16 E7 Oncoprotein Changes with Cell Confluence Joanna Laurson*, Kenneth Raj¤ Division of Virology, National Institute for Medical Research, Medical Research Council, London, United Kingdom Abstract E7 is one of the best studied proteins of human papillomavirus type 16, largely because of its oncogenic potential linked to cervical cancer. Yet the sub-cellular location of E7 remains confounding, even though it has been shown to be able to shuttle between the nucleus and the cytoplasm. Here we show with immunocyto