选择性5-羟色胺再摄取抑制剂应用和评价.pdfVIP

选择性5一羟色胺再摄取抑制剂应用与评价 张石革(北京大学第四I临床医学院北京积水潭医院，北京市100035) 中图分类号 R971+．43文献标识码 B 文章编号 1672—2124{2007)03—0172—04 摘要 目的：抑郁症是神经内科的常见舜口多发病，伴随着对抑郁发病机制的解译，治疗新药不断问世，本文介绍选择性5一羟色 胺再摄取抑制剂进展和临床应用的侧面。方法：采用国内、外文献综述方法。结果及结论：作为抗抑郁药中的一支奇葩，选择性 5一羟色胺再摄取抑制剂进展迅猛，对5一HT受体有高度的选择性，标志一个新的里程的开始，从而在解除抑郁症上展现了良好 的治疗前景。 关键词 抑郁症；选择性5一羟色胺再摄取抑制剂；单胺氧化酶抑制剂；三环类抑郁药；选择性去甲肾上腺素再摄取抑制剂；5一羟 色胺受体拮抗剂／再摄取抑制剂 and oftheSelectiveSerotonin Inhibitor Evaluation Application Reuptake ZHANG Jishuitan TouthClinicalMedical of Shige(BeijingHospital，The CollegeBeijing 100035，China) ABSTRACT disorderisacommonand encountereddiseasein of OBJECTIVE：Depressive frequently department withthe ofits andthe ofnew ofour isto appearifigantidepressantdrags．Theobjective understandingpathogenesis study introducethe andclinical ofselectiveserotonin was progress application reuptake analysis literaturebothathomeandabroad．RESULTSCONCLUSION：Asanew performedbyreviewing antidepressantdrug。 selectiveserotonin inhibitor a the thatselectiveserovtonin reuptake experiencedrapidprogress；andfinding reuptake was inmedicinesinceitshowed for of is selectiveto5一HT amilestone a the highly receptors satisfactoryprospectrelieving orders． depressive KEYWORDS Serotonin Oxidase disorder；Selective Depressive Reuptake Noradrenalin (MAOI)；Tricyclicantidepr