超重肥胖儿童的脂代谢异常与INSIG2基因的关联研究.pdfVIP

·650· ·现场调查· 超重肥胖儿童的脂代谢异常与INSIG2 基因的关联研究 王海俊张衡张饭王燕马军 【摘要】 目的研究儿童超重肥胖和脂代谢与胰岛素诱导基因2(朋，G2)变异的相关性。 方法选择北京市2030名7～18岁的儿童进行身体测量及血脂、INSIG2基因rsl3428113多态性检 测。结果研究对象rsl3428113多态性的等位基因突变率(rc)为49．3％。比较体重正常、超重 和肥胖组基因型及等位基因频率，发现三组差异无统计学意义(P0．05)。在超重组中CC基冈型 携带者的体重指数、腰臀比、肱三头肌和髂前上棘皮褶厚度高于TT／TC基因型携带者；在肥胖组中 CC携带者总胆固醇水平高于删粥携带者(P0．05)。结论删_s，G2基因rsl3428113多态性与超 重肥胖儿童的脂代谢异常有关，可能加重肥胖、血脂异常程度。 【关键词】肥胖；儿童；INSIG2基因 Associafionof metabolismwithlNslG2variantin andobese abnormal、ipid gene overweight childrenWANG Heng，zHANcJi。WANGYan，MAJun．Division and Hai-jun，zHANG ofMaternal D，．Publw Child胁础th．SchoolHealth。PekingUniversity，曰eijing100191，China Correspondingauthor：^拟Jun，Email：majunt@bjmu．edu．cn 死蠡workwas the supponedgrantsfiomSpecializedResearch几，ld加舭DoctoralProgramofHigher by NaturalScienceFoundation the Education(No．20070001811)：NationalofChina(Noand NationalBasicResearch Programo，China(973Program)(No．2006CB503900) To the betweeninsulininduced2(，ⅣS，G2) 【Abstract】Objectivestudyrelationship gene in total variantand or metabolismChinesechildrenandadolescents．MethodsA obesitylipid numberof2030 atthe from7tol8 wereselectedin schoolstudentsage years Beiiing．Physical indicators．serumandthersl3428113 wereexaminedforallthe lipids polymorphismiIl价『S，(芝gene Theoverallmutationrateofthersl3428113 4913％． subjeets．Results polymorphism(TC)was Thedifferencesof andallele werenot genotype frequencies statisticallysignificantamong and the stu