wnt_beta;-catenin 信号通路对动物卫星细胞向不同肌纤维类型分化的作用.pdfVIP

中国农业科学 2012,45(7): 1380-1386 Scientia Agricultura Sinica doi: 10.3864/j.issn.0578-1752.2012.07.016 wnt/β-catenin 信号通路对动物卫星细胞向不同 肌纤维类型分化的作用 史新娥, 刘月光, 杨秋梅, 陈宗正, 杨公社 （西北农林科技大学动物科技学院/动物脂肪沉积与肌肉发育实验室，陕西杨凌 712100 ） 摘要：动物出生后骨骼肌在生长发育和再生过程中，卫星细胞发挥着十分重要的作用，其分化及形成肌 纤维的类型与肉品质密切相关，wnt/ β-连环蛋白(β-catenin)信号通路是调节此过程的重要信号通路。近 几年，wnt/ β-catenin 信号通路在骨骼肌生长和再生过程中的作用及机制研究受到人们的重视，已积累了 一些相关研究成果。本综述系统阐述了wnt/ β-catenin 信号通路在卫星细胞自我更新、分化以及肌纤维类 型形成中的作用。 关键词：wnt/ β-catenin；卫星细胞；肌纤维类型 Role of wnt/β-catenin in the Differentiation of Satellite Cells into Muscle Fibers SHI Xin-e, LIU Yue-guang, YANG Qiu-mei, CHEN Zong-zheng, YANG Gong-she (College of Animal Science and Technology, Northwest AF University/Laboratory of Animal Fat Deposition and Muscle Development, Yangling 712100, Shaanxi) Abstract: Satellite cells are established as the major stem cells contributing to gowth and development as well as regeneration of skeletal muscle. Differentiation of satellite cell and muscle fiber type formation are closely related to meat quality. wnt/β-catenin is an important pathway regulating these events. Recently, more and more research focused on skeletal muscle growth and regeneration regulated by wnt/β-catenin. And many interesting results are published. The role of wnt/β-catenin in the differentiation of satellite cells into different type of muscle fiber and turn -over was reviewed. Key words: wnt/β-catenin; satellite cells; muscle fiber types [2] 骨骼肌占动物体重的 40%—50%，是重要的畜产 即 PSE ） 。肌内脂肪是评价肉质的关键指标之一， 品。肉品质主要取决于肌纤维（肌细胞）类型和肌内