Promotion and prevention of autoimmune disease by CD8+ strongTstrong cells.pdfVIP

Journal of Autoimmunity xxx (2013) 1 e12 Contents lists available at SciVerse ScienceDirect Journal of Autoimmunity journal homepage: www.elsevi /locate/jautimm Review Promotion and prevention of autoimmune disease by CD8þ T cells David M. Gravano, Katrina K. Hoyer* Department of Molecular Cell Biology, Health Sciences Research Institute, University of California, Merced, CA, USA a r t i c l e i n f o a b s t r a c t Article history: Until recently, little was known about the importance of CD8þ T effectors in promoting and preventing Received 10 June 2013 autoimmune disease development. CD8þ T cells can oppose or promote autoimmune disease through Accepted 10 June 2013 activities as suppressor cells and as cytotoxic effectors. Studies in several distinct autoimmune models and data from patient samples are beginning to establish the importance of CD8þ T cells in these dis- Keywords: eases and to define the mechanisms by which these cells influence autoimmunity. CD8þ effectors can Autoimmune disease promote disease via dysregulated secretion of inflammatory cytokines, skewed differentiation profiles CD8þ T cell and inappropriate apoptosis induction of target cells, and work to block disease by eliminating self- Tolerance reactive cells and self-antigen sources, or as regulatory T cells. Defining the