中药和中药有效成分治疗阿尔茨海默病的研究进展.pdfVIP

2008 2 28 2 CJITWM, February 2008, Vo.l 28, No. 2 177 综 述 赵敬堃 王德生 为促进中药有效成分治疗阿尔茨海默病的进一步发展, 深 进行治疗阿尔茨海默病中药有效成 分和靶点的研究, 对近年来有代表性的文献进行分析归纳 阿尔茨海默病; 中药; 有效成分 Progress of S tudy on Treatm ent of A lzheim er s D isease w ith Active Ingredien ts of Ch in ese H erba lM ed i cin es ZHAO Jingkun andWANG Des engDepartment of N eurology, the F irstAff iliatedH osp ital of H arbinM edical University,H arbin (15 1) A bstract In order to advance t e treatment ofA lz emi er s d isease w it active ingredients of C inese erbal med icines and t e researc on t ese ingredients and t eir effective targets in treating t e d isease, t e relative repre sentative literatures publis ed in recent yearsw ere review ed and summarized in t is paper. K ey words A lz emi ers d isease; trad itionalC inese med icine; active ingred ient , AD , , !1∀ , 65~ 85, 10% AD, ( A lz emi er s disease, AD), 85 , , , AD, , ; , AD , AD 1906A lois A lz emi er , , AD , AD AD, AD 1 ( Ginkgo biloba L. ) ( amyloid beta, A) , !2∀ , , , AD !4 ∀ , , A, AD , ( neurofibrillary tangles, NFTs), , !3∀ , ; EGb 761 AD , AAD A , , 6: ( 1) , APP , A NO A( 2)A( 3) , ; !5- 7∀ ( 4), A( 5) , EGb ( 6) 761 I ( HO1), AD : ( No. ;