a novel interaction between calcium-modulating cyclophilin ligand and basigin regulates calcium signaling and matrix metalloproteinase activities in human melanoma cells：一种新型钙调节亲环素配体之间的相互作用，其调节钙信号和人黑色素瘤细胞基质金属蛋白酶活性.pdfVIP

Cancer Letters 339 (2013) 93–101 Contents lists available at ScienceDirect Cancer Letters journal homepage: www.else /locate/canlet A novel interaction between calcium-modulating cyclophilin ligand and Basigin regulates calcium signaling and matrix metalloproteinase activities in human melanoma cells Tingting Long a,1, Juan Su a,1, Wen Tang a, Zhongling Luo a, Shuang Liu a, Zhaoqian Liu b, Honghao Zhou b, Min Qi c, Weiqi Zeng a,⇑, Jianglin Zhang a,⇑, Xiang Chen a,⇑ a Department of Dermatology, XiangYa Hospital, Central South University, Changsha, Hunan, China b Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, Hunan, China c Department of Plastic Surgery, XiangYa Hospital, Central South University, Changsha, Hunan, China a r t i c l e i n f o a b s t r a c t Article history: Intracellular free calcium is a ubiquitous second messenger regulating a multitude of normal and path- Received 8 May 2013 ogenic cellular responses, including the development of melanoma. Upstream signaling pathways regu- Received in revised form 11 July 2013 lating the intracellular free calcium concentration ([Ca2+ ]i) may therefore have a significant impact on Accepted 15 July 2013 melanoma growth and metastasis. In this study, we demonstrate that the endoplasmic reticulum (ER)- associated protein calcium-modulating cyclophilin ligand (CAML) is bound to Basigin, a widely expressed