原创力文档a novel label-free electrochemical mirna biosensor using methylene blue as redox indicator application to breast cancer biomarker mirna-21：一种新型无标记的电化学生物传感器，利用mirna亚甲蓝作为氧化还原指示剂对乳腺癌生物标志物的微小rna-21应用.pdfVIP
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a novel label-free electrochemical mirna biosensor using methylene blue as redox indicator application to breast cancer biomarker mirna-21：一种新型无标记的电化学生物传感器，利用mirna亚甲蓝作为氧化还原指示剂对乳腺癌生物标志物的微小rna-21应用
Biosensors and Bioelectronics 77 (2016) 202–207
Contents lists available at ScienceDirect
Biosensors and Bioelectronics
journal homepage: /locate/bios
A novel label-free electrochemical miRNA biosensor using methylene
blue as redox indicator: application to breast cancer biomarker
miRNA-21
Hossain-Ali Rafiee-Pour a,n, Mohsen Behpour b, Mahin Keshavarz b
a Biotechnology Division, Department of Molecular and Cell Biology, Faculty of Chemistry, University of Kashan, Kashan, Iran
b Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, Iran
a r t i c l e i n f o a b s t r a c t
Article history: Small noncoding microRNAs (miRNAs) have emerged as ideal noninvasive biomarkers for early-phase
Received 6 July 2015 cancer detection. In this report, a label-free and simple electrochemical miRNA biosensor is developed
Received in revised form based on employing methylene blue (MB) as a redox indicator. The successfully immobilization of the
3 September 2015 single strand DNA (ss-DNA) probe and hybridization with the target miRNA sequence were confirmed by
Accepted 10 September 2015
electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) methods. Differential pulse
Available online 16 September 2015
voltammetry (DPV) technique was used to record the oxidation peak current of MB under optimal
Keywords: condition and an increase in
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