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a robust possibilistic programming approach for pharmaceutical supply chain network design：医药供应链网络设计稳健式的编程方法.pdf

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a robust possibilistic programming approach for pharmaceutical supply chain network design：医药供应链网络设计稳健式的编程方法

Computers and Chemical Engineering 82 (2015) 115–128 Contents lists available at ScienceDirect Computers and Chemical Engineering j o u r na l h o me p a g e : w w w. elsev /locate/compchemeng A robust possibilistic programming approach for pharmaceutical supply chain network design M. Mousazadeh, S.A. Torabi ∗ , B. Zahiri School of Industrial Engineering, College of Engineering, University of Tehran, Tehran, Iran a r t i c l e i n f o a b s t r a c t Article history: In this paper, a bi-objective mixed integer linear programming (BOMILP) model is developed for a phar- Received 1 August 2014 maceutical supply chain network design (PSCND) problem. The model helps to make several decisions Received in revised form 17 May 2015 about the strategic issues such as opening of pharmaceutical manufacturing centers and main/local dis- Accepted 20 June 2015 tribution centers along with optimal material ﬂows over a mid-term planning horizon as the tactical Available online 3 July 2015 decisions. It aims to concurrently minimize the total costs and unfulﬁlled demands as the ﬁrst and second objective functions. Since the critical parameters are tainted with great degree of epistemic uncertainty, Keywords: a robust possibilistic programming approach is used to handle uncertain parameters. In order to verify Pharmaceutical supply chain network design and analyze the proposed model, it is tested on a real case study and managerial insights are provided. Robu