miR126功能的多效性和先天性免疫.pdfVIP

Hereditas (Beijing) 2014 年7 月, 36(7): 631 ―636 综 述 miR126 功能的多效性与先天性免疫 白玉, 陆雯芸, 韩凝, 边红武, 朱睦元 浙江大学生命科学学院遗传所, 杭州 310058 摘要:MicroRNAs (miRNAs)是一种重要的转录后水平进行调控的非编码小分子RNA 。目前已发现许多miRNAs 参与细胞增殖、分化、发育及凋亡等复杂的生物进程, 其中miR126 是一种来源于Egfl7 第7 个内含子的保守型 内含子 miRNA, 主要在哺乳动物的内皮细胞(Endothelial cells, ECs)及浆细胞样树突状细胞(Plasmacytoid den- dritic cells, pDCs) 内表达, 参与血管的新生及癌细胞的增殖与迁移。最新的研究表明, miR126 是迄今唯一参与先 天性免疫平稳期病毒应答反应的miRNA, 预示着miR126 有可能成为治疗癌症及免疫缺陷病的靶标分子。文章 综述了miR126 在血管新生和癌症中的功能, 并着重介绍了miR126 与先天性免疫的关系。 关键词: miR126 ; 血管新生; 癌症; 先天性免疫 Functions of miR126 and innate immune response Yu Bai, Wenyun Lu, Ning Han, Hongwu Bian, Muyuan Zhu Institution of Genetics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China Abstract: MicroRNAs (miRNAs) are endogenous non-coding small RNAs that negatively regulate gene expression at the post-transcriptional level by base pairing with target mRNAs. Many miRNAs have been proven to regulate a broad range of processes, including proliferation, differentiation, development and apoptosis. miR126 is encoded by intron 7 of the EGF- like domain 7 (Egfl7) gene and highly expressed in human endothelial cells (ECs) and plasmacytoid dendritic cells (pDCs). Based on the current knowledge, miR126 is involved in angiogenesis and cancer. Also miR126 is the first miRNA which has been reported to involve in preconditioning the responsiveness of the host to pathogen infection in the steady state. This implicated that miR126 may be the potential therapeutic target for cancer and autoimmune diseases. In this review, we summarize the functions of miR126 in angiogenesis and cancer, and emphasize its relationship with innate immune