β1ar阻断剂合β2ar激动剂对心梗大鼠心功能的影响及机制.pdf

: 10114 : 201020642 1AR 2AR The Effect and Mechanism of Combined Therapy with 1 AR Blocker and 2 AR Agonist on Cardiac Function in rats of post-myocardial Infarction 1 Abstract3 5 6 12 16 18 19 21 30 35 38 39 1AR 2AR M T L A S 8 1 M 20mg/kg T 2mg/kg L A 8 GSH/GSSG bax/bcl-2 A LVEDD LVESD P 0.05 EFFS P 0.05 T L M P0.05 A LVEDP P 0.05 LVSP ±dp/dt P 0.05 L M P 0.05 T M LVEDP P 0.05 A GSH P 0.01 GSSG P 0.01 L P 0.05 T M GSH P 0.05 A bcl-2 P 0.01 bax P 0.01 T L bax P=0.141 M P 0.05 L bcl-2 S P=0.453 bcl-2 P=0.132 L L bcl-2/bax T T bcl-2/bax M 1 2 The effect and mechanism of combined therapy with 1 AR blocker and 2 AR agonis