药物性肝病71临床分析.pdfVIP

摘 要 目的探讨药物性肝病的病因和临床特点，以帮助临床医师更合 理的用药，为药物性肝病的诊治提供临床资料。 方法采用回顾性分析方法对71例药物性肝病住院患者的用药 史，临床表现，肝功能检查，病原学标志以及治疗转归进行了训查分析。 结果引起肝病的相关药物中，中药占23．9％(17／71)，抗结核类 中枢神经系统用药占2．8％(2／71)。临床表现多样，无特异性，l例为 重症肝炎。临床分型以胆汁淤积型最常见42．3％(30／71)，其次为肝细 药并给予保肝等治疗，70例预后良好(98．6％)，有1例发展为肝硬化。 结论 (1)本组药物性肝病主要由中药、抗结核药、抗生素类药引起。 (2)药物性肝病主要类型为ilH_}If淤积型，其次为肝细胞型。 (3)绝大多数药物性肝病的预后良好，个别病例可出现重症肝炎 和肝硬化。 关键词药物；肝病；,tjH{，L淤积；肝细胞损伤；预后 Abstract Clinical of liverdisease analysisdrug-induced Theaimofthe WaStoexaminethe Ojective presentstudy etiology andclinicalmanifestationof with liverdisease drug-induced patients and theclinicianstouse more help drugs reasonably Methods with liverdiseasewere patientsdrug-induced Seventy-one examined whichhadbeen and drugs used，clinicalsymptomsigns，laboratory testand iceffect therapeut was ResultsIt thatthe of whichinducedliver suggested drugs proportion diseaseweretraditionalchinamediCine 12．7％(9／71) drugs The clinicalrmnifestationwerediverseandhadno dominating particularity One was most were s．The patienthepatitisgravi types Themost werecuredwith became patients goodprognosis98．6％onepatient CII