微小剂量阿司匹林对正常小鼠和高尿酸血症模型小鼠血尿酸的影响.pdfVIP

微小剂量阿司匹林对正常小鼠及高尿酸血 症模型小鼠血尿酸的影响 1 2 1 张海英 卓来东 李玉珍 （1.北京大学人民医院药剂科，北京 100044 2.北京大学药学院，北京 100083 ） 摘要：目的 考察微小剂量阿司匹林对正常小鼠和高尿酸血症模型小鼠血尿酸、肌酐、尿素 氮的影响。方法 120 只小鼠，随机分为 8 组，分别为正常对照组、高尿酸血症模型对照组、 正常给药组（3 组）和高尿酸血症模型给药组（3 组）。2 组对照组分别给予 0.5 ％羧甲基纤 维素钠溶液，给药组按照 12.5mg/kg、25mg/kg 、50mg/kg 的给药剂量分别给予阿司匹林溶液， 每天 1 次，持续一周。一周后，正常阿司匹林给药组在灌胃结束 1 小时后取血，正常对照组 立即腹腔注射 0.5 ％CMC-Na，高尿酸对照组和阿司匹林实验组则腹腔注射尿酸溶液，并于 注射后 1 小时取血样测定尿酸、肌酐和尿素氮。结果 微小剂量阿司匹林对正常和高尿酸血 症模型小鼠的肌酐、尿素氮影响不明显，但可显著升高血尿酸水平，在给药剂量为 12.5mg/kg 时，升高比率最大。随给药剂量增加，血尿酸水平逐渐回落至基线，与对照组相比无显著性 差异。结论 微小剂量阿司匹林可导正常小鼠和致高尿酸血症模型小鼠血尿酸水平升高，且 随给药剂量增加，这种影响减小。患者特别是痛风和高尿酸血症患者在应用微小剂量阿司匹 林时应注意监测血尿酸浓度。 关键词：阿司匹林；高尿酸血症模型；血尿酸；肌酐；尿素氮 The effect of mini-dose aspirin on uric acid in normal mice and hyperuricemia model mice ZHANG Hai-ying, LI Yu-zhen (Department of Pharmacy, People’s Hospital, Peking University, Beijing 100044, China) ZHUO Lai-dong (School of Pharmaceutical Sciences, Peking University, Beijing 10083, China) ABSTRACT: OBJECTIVE The aim of study was to evaluate the effects of mini-dosages of aspirin on blood uric acid, creatinine and urea nitrogen in normal mice hyperuricemia model mice. METHODS 120 mice were randomized into 8 groups, consists of normal controlled group, hyperuricemia controlled group, normal experimental group (3 groups) and hyperuricemia experimental group (3 groups) . normal and hyperuricemia controlled groups were administrated 0.5% CMC-Na, normal and hyperuricmia experimental groups were administered aspirin as follow: 12.5mg/kg/d, 25mg/kg/d, 50mg/kg/d. The dosage of CMC-Na and aspirin keep a week. Then normal experimental groups blood was collected 1 hour later after the last administration for determination uric acid, creatinine and urea nitroge