新型1,5-苯并硫氮衍生物的合成和晶体结构.pdfVIP

2009 年第 29 卷 有 机 化 学 Vol. 29, 2009 第 3 期, 414～419 Chinese Journal of Organic Chemistry No. 3, 414～419 ·研究论文· 新型 1,5-苯并硫氮衍生物的合成和晶体结构 叶嘉炜 a 杨 春 b 杨德保 b 刘方明*,a,b (a 新疆大学化学化工学院 乌鲁木齐 830046) (b 杭州师范大学材料与化学化工学院 杭州 310036) 摘要 以 β -二甲胺基苯丙酮盐酸盐为原料, 经过羟醛缩合, 与邻氨基硫酚的环化, 最后与氯乙酰氯的[2＋2]环加成反 应, 合成了 8 种未见文献报道的新化合物, 其结构经 IR, 1H NMR 和 MS 及元素分析确证. 利用单晶 X 射线衍射法测定 了化合物 4e 的晶体结构. 关键词 1,5-苯并硫氮杂; β - 内酰胺; 晶体结构 Synthesis and Crystal Structure of Novel Derivatives of 1,5-Benzo[b]thiazepine Ye, Jiaweia Yang, Chunb Yang, Debaob Liu, Fangming*,a,b a ( College of Chemistry and Chemical Engineering, Xinjiang University , Urumqi 830046) (b College of Materials and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036) Abstract Eight title compounds were synthesized by the multi-step reaction using β -dimethylamino- propiophenone hydrochloride as stating materials, followed by aldol condensation, cyclization with o-aminothiophenol, and [2 ＋2] cycloaddition reaction with chloroacetyl chloride. The structures of these 1 compounds were characterized by H NMR, MS techniques and elemental analysis. Compound 4e was sub- jected to single crystal X-ray diffraction analysis to determine their structure. Keywords 1,5-benzothiazepine;β -lactam; crystallographic structure 1,5-苯并硫氮杂及其衍生物是一类具有重要生理 对抗细菌的抗药性. 这项工作对于以后能筛选具有广谱 活性的含硫、氮杂环化合物,