嘧啶类化合物的合成及抗菌活性研究进展.pdfVIP

2009 年第 29 卷 有 机 化 学 Vol. 29, 2009 第 3 期, 365～379 Chinese Journal of Organic Chemistry No. 3, 365～379 ·综述与发展· 嘧啶类化合物的合成及抗菌活性研究进展 吴 琴 宋宝安* 金林红 胡德禹 (贵州大学精细化工研究开发中心 教育部绿色农药和生物工程重点实验 贵阳 550025) 摘要 嘧啶类化合物因其广泛的生物活性在医药、农药等领域备受关注. 将不同基团引入嘧啶结构中, 经过结构修饰 能产生一系列具有抗菌活性的嘧啶衍生物, 它在新型农药创制中发挥着越来越重要的作用. 对嘧啶类化合物的合成及 杀菌活性的研究进行了分类综述, 并展望了它的发展趋势和应用前景. 关键词 嘧啶; 合成; 抗菌活性 Research Advances in Synthesis and Antifungal Activity of Pyrimidine Compounds Wu, Qin Song, Baoan* Jin, Linhong Hu, Deyu (Key Laboratory of Green Pesticide and Agriculture Bioengineering of Ministry of Education, Research and Development Center for Fine Chemicals, Guizhou University, Guiyang 550025) Abstract Pyrimidine compounds have been the subject of much attention in pesticide and medicine fields owing to their unique biological properties. In addition, the introduction of different groups into pyrimidine structures can generate a series of pyrimidine compounds with antifungal activity, which have played an important role in pesticide application. The synthesis and antifungal activity research for pyrimidine com- pounds are reviewed. The developing trends and application prospects of pyrimidine compounds are also discussed. Keywords pyrimidine; synthesis; antifungal activity 嘧啶是一类非常重要的杂环化合物, 广泛应用于医 物、马铃薯、蔬菜和咖啡等作物中几乎所有真菌纲(子 药、农药领域. 大量研究表明该类化合物具有较好的生 囊菌纲、担子菌纲、卵菌纲和半知菌类)病害. 由于嘧啶 物活性, 如杀虫、杀菌、除草、抗病毒、抗癌等[1～8]. 自