程序性核糖体移码讲解.pptVIP

* The research of Programmed –1 ribosomal frameshifting (-1PRF) lecturer ： INTRODUCTION Programmed ribosomal frameshifting (PRF) is a recoding event that leads to a change of the translational reading frame and allows the translation of messenger RNAs (mRNAs)with overlapping open reading frames, often yielding two protein products from one mRNA. During PRF, the reading frame may shift in +1, –1, or even –2 direction. The mechanisms of +1 and –1PRF appear to be quite different and require a different set of stimulatory elements. INTRODUCTION The classic example of -1PRF is slippage tri