notch-1nf-κb和β-catenin在口腔鳞状细胞癌中的表达及其临床意义.pdfVIP

摘要 发展过程中地作用。 方法g应用免疫组织化学染色方法检测了58例口腔鳞状细胞癌组织及30例癌 系。 结果：ONotch．1，NF．r,B蛋白在口腔鳞状细胞癌组织中地表达明显高于在癌 周组织，并且两者染色积分间地差异具有显著性(P0．05)。两种蛋白地表达水平与 患者地年龄、性别、肿瘤原发部位和组织学分级之间无相关性，但是与肿瘤TNM 分期以及有无淋巴结转移密切相关(P0．05)。②在58例口腔鳞状细胞癌组织中p． 见现象，并且三者表达情况均与肿瘤TNM分期以及有无淋巴结转移密切相关。 但NF．r,B表达和p．catenin异位表达无明显相关性。 Abstract OHective：Tothe ofNotch．1，NF．rB investigate and inoral expression 13-catenin cell discusstheir squamousCarcinoma,and associationand withthe relationship features． clinicopathological Methods：Theof Notch一1，NF．r．Band expression 13-catenin in58 wereanalysed oral cell carcinomaand30 squamous samples normaltissues to morphologicallyadjacent the carcinomas using immunohistochemistry． Results：Notch-1andNF-lcB were proteindemontratedtobe inmost up．regulated oraI eellcarcinomathaninnormal squamous tissues samples by Andthe differencein scores weightedbetweenthesetwo Was groupsignificant(P0．O1)． therewereno Although correlationbetween ofNotch．1，NF．rd3 expression and protein some tumourclinical