中医综合治疗肝亏虚型大骨节病的临床研究.pdfVIP

摘 要 目的：采用循膀胱经背俞穴弹拨法、针刺结合大骨节II 号胶囊治疗大骨节 病病，客观评价其安全性及有效性。 方法：将 104 例患者随机分为两组，治疗组采用循膀胱经背俞穴弹拨法、 针刺结合大骨节 II 号胶囊治疗，对照组采用亚硒酸钠片、布洛芬缓释胶囊、维 生素C 片联合治疗，两组均治疗90 天，在停止治疗3 个月及6 个月后各随访 1 次。以视觉模拟评分法、膝关节功能评分及藏族成人大骨节病患者生活质量评分 为观察指标。 结果：试验入组104例，随机分配至治疗组和对照组，每组各52例，治疗组 剔除4例，脱落5例，对照组剔除2例，脱落6例，符合方案分析87例。治疗前两组 在性别、年龄、病程、分度分布方面及病情评估指标（VAS评分、膝关节功能评 分、藏族成人大骨节病患者生活质量评分）的比较方面差异无统计学意义 (p0.05)，具有可比性。治疗3个月后，治疗组治愈率44.19%，对照组治愈率 11.36%；停止治疗3个月后，治疗组治愈率47.37%，对照组治愈率5.26%，两组组 间病情评估指标比较差异有统计学意义（p0.05）；停止治疗6个月后，治疗组治 愈率43.75%，对照组治愈率5.88%，两组组间病情评估指标比较差异有统计学意 义(p0.01)。 结论：(1)循膀胱经背俞穴弹拨法、针刺结合大骨节II号胶囊治疗大骨节病 膝关节病变安全有效。 (2)循膀胱经背俞穴弹拨法、针刺结合大骨节II号胶囊治疗方案与亚 硒酸钠片、布洛芬缓释胶囊、维生素C片联合治疗方案的近期疗效相当，远期疗 效前者优于后者。 关键词：大骨节病 肝肾亏虚气滞血瘀型 循膀胱经背俞穴弹拨法 大骨节 II 号胶囊 临床研究 ABSTRACT Objective: To observe the effect of treating Kashin-Beck Disease by flicking back-shu points follow bladder meridian combined with acupuncture and DaGuJie II capsule,and evaluate its safety and effectiveness objectively. Methods: 104 patients were divided into 2 groups in random. The treatment group were treated with flicking back-shu points follow bladder meridian, and acupuncture ,and DaGuJie II capsule. The control group take Sodium Selenite Slice , and Fenbid , and Vitamin C tablets. Both groups treatment for ninety days.When the treatment finish, following-up 1 time three months after and six months after.Use VAS and Lequesne index and Quality of life of adult patients with Tibetan to be observing indexes. Result: 104 patients were involved in this trial, and divided into 2 groups in random. each group of 52 cases, the treatment group eliminate 4 cases, fall off 5 cases and control group eliminate 2 cases, fall off 6 cases ,left 80 cases. The comparison of two groups before treatment on sex, age, duration, dividing distributi