复心汤抗心力衰机制及其临床疗效的研究.pdfVIP

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复心汤抗心力衰机制及其临床疗效的研究.pdf

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复心汤抗心力衰机制及其临床疗效的研究

The study of Mechanism and Clinical efficacy of Fu Xin Decoction on Heart Failure Speciality: Internal Medicine of TCM Author: Gao Yang Tutor: Prof.Xue Yitao Abstract Objective: To explore the mechanisms and provide theoretical basis for clinical use of Fu xin decoction through the observation of the decoction on Adriamycin (Adriamycin, ADR)-induced effect of myocardial cell apoptosis in CHF rats，and to observe clinical curative effect of Fu xin decoction on patients with CHF. Methods ：Basic research ：Established heart failure rat model induced by ADR. 60 male Wister rats, randomly divided into 5 groups, blank-control group, model group, Fu xin decoction in the low-dose group, Fu xin decoction in the high-dose group, the captopril group, per set of 12. After 6 weeks of drug intervention, determining the success of model through the detection of cardiac function. Semi-quantitative analysis on myocardial Caspase-8 mRNA and Bcl-2 mRNA by RT-PCR. Clinical observation ：Randomly selected 64 cases of inpatients met the inclusion criteria of CHF, into treatment group(32 cases)and control group(32 cases). Control group treated by conventional Western medicine, treatment group in Fu xin decoction rushing on the basis of conventional Western medicine Effects were observed after 2～4 weeks’ treatment. Results: Basic research ：The model group rats show obvious symptoms of heart failure. The symptom of the other treatment groups is lighter than the model group. Compared with the model group, the other treatment groups upregulated its Caspase-8, Bcl-2 downregulated significantly. Clinical observation ：After the course of treatment , significant difference was apparent in the clinical effects:In the treatment group,the