补肾活血汤对慢心衰大鼠心肌胶原ⅰ、ⅲ型及水通道蛋白2的影响.pdfVIP

Kidney invigorate the method to chronic heart failure rats myocardial collagen type I, III and water channel protein2 expression Speciality：Medical Department of TCM Author: ZHU Dong-dong Tutor：Prof. LI Jie Abstract Objective: to study the kidney huoxue soup of traditional Chinese medicine to spontaneously hypertensive rats caused by heart failure myocardial collagen I and III type and the water channel protein expression of HFCL 2, evaluation of the kidney huoxue soup heart failure model of rats curative effect, and analyzes the characteristics and the possible role of mechanism, the kidney huoxue soup for the clinical promotion provide experimental and theoretical basis. Methods: the 32 ZhouLing spontaneously hypertensive rats (SHR) 60 only randomly divided into 5 groups (the only 12), Chinese medicine, Chinese medicine in high dose group of dose group of traditional Chinese medicine, low dose group, enalapril group, the model control group and the remaining 12 Wistar rat only for WKY group, the treatment group were given filling kidney huoxue soup of high, middle and low dose and enalapril fill the stomach, the model control group and WKY were given the same doses of distilled water irrigation stomach, irrigation 10 ml/kg stomach for eight weeks to medicine, the myocardial type I collagen, Ⅲ collagen type and kidney water channel protein expression level of 2. Results: 1. Filling kidney invigorate the high dose group and group therapy compared with model after myocardial type I collagen, Ⅲ collagen type and kidney water channel protein expression level of 2, there was a significant difference was statistically significant (P 0.01), in the kidney invigorate the dose group of treatment group