丹参注射液关节注射预防关节粘连的实验研究.pdfVIP

目 录 中文摘要 ················································1 英文摘要 ················································4 符号说明 ················································8 引 言 ················································9 正 文 ···············································11 1.实验材料和方法·····································11 1.1 实验材料···········································11 1.1.1 实验动物 ········································11 1.1.2 实验药物及器材 ·································12 1.2 实验方法···········································12 1.2.1 实验分组 ········································12 1.2.2 实验造模 ········································12 1.2.3 实验动物标本采集 ······························12 1.2.4 统计学处理 ·····································16 2. 实验结果············································16 2.1 一般情况 ···········································16 2.2关节活动度测量 ····································16 2.3关节粘连大体观察 ·································17 2.4髌上囊前壁滑膜组织病理学观察··················18 2.5总胶原含量 ········································18 3.讨 论············································19 3.1 中国传统医学对关节粘连的认识 ··················19 3.2 关节粘连的病因及发病机制 ·······················21 3.2.1关节粘连的病因 ·································21 3.2.2关节粘连的发病机制 ····························22 3.2.3影响关节粘连形成的主要生化因素 ··············23 3.3 动物造模 ···········································31 3.3.1关节粘连动物模型 ·······························31 3.3.2 固定位置 ········································31 3.3.3 手术方法 ········································31 3.3.4理想的造模方法 ·································31 3.3.5用药频次、观察时间及观察点的选择 ···········32 3.3.6评价指标的选择 ·································33 3.4 用药依据 ··········································36 3.5 现代医学对丹参的认识 ···························38 3.5.1改善局部缺血的作用及机制 ·····················38 3.5.2 抗炎作用 ········································39 3.5.3丹参抗纤维化的作用及机制 ·····················40 3.5.4丹参预防关节粘