心宁片对心梗后鼠心肌的保护作用及对VEGF,FLK-1表达的影响.pdf

Abstract The thoracic obstruction syndrome of traditional Chinese medicine,what is equivalent to angina of coronary heart disease in modem medicine, is a disease that the patients mainly showed the symptom of pectoralgia even chest and back pain, short breath, incapability of supination because of gasp.It is common ailment and hypertrichosis in clinical.It is harmful to peoples health and the development of society. So it is direct economic and extensive social value to research a kind of safe and efective drug of anti-myocardial ischemia. XinNing Tablet is made of the active constituent which caused by the compatibility of Radix Astragali Radix Salviae MiltiorrhiaeRadix Notoginseng and Rhizoma Chuanxiong etc. It is the optimization and screening of the empirical formula which names HuXinKang tablet.This task has observated the XinNing tablet effect and mechanism for the vascular endothelial growth factor(ZEBRA) promotion to the new vessels as well as the protection and mechanism for the establishment of the collateral circulation at late stage of myocardial damage in myocardial ischemia animal model.From the task we confirm the XinNing tablet’s certain drug action for the cardiovascular system(CVS). In the project, we observed the protective efect of Xinning tablets on the milli-volt of ST segment electrocardiogram and the myocardium damage of animal model of myocardial ischemia, inquired into the mechanism, proved its possibility to be the good substitute for mask, and study deeply the mechanism on myocardium of promoting blood circulation by removing blood stasis to the thoracic obstruction syndrome.We adopted the myocardial ischemia rat model by ligaturing their left front-fall branch of coronary artery, and observ