SOLVD研究PPT课件.pptVIP

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SOLVD研究PPT课件.ppt

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Benefits of Enalapril Patients: Symptomatic HF patients with LVD (EF 35%) Decreased hospitalizations 48% at 3 months 51% at 6 months 46% at 12 months 23% at 24 months 28% at 36 months 30% reduction of overall hospitalization at end of study (P0.0001) Convenient once - or twice - daily dosing Enalapril - Dosing SOLVD(Studies of Left Ventricular Dysfunction) Enalapril vs placebo in 6,794 patients Ejection fraction 35% End points include: Delaying the progression of heart failure Improving signs and symptoms Reducing mortality Treatment arm - 2,568 symptomatic class II-III patients most on digitalis and diuretics Prevention arm - 4,226 asymptomatic class I-II patients, most on no concomitant therapy N Engl J Med 1991:325:293-302 SOLVD Treatment TrialAll Cause Mortality N Engl J Med 1991;325:293-302 16% Risk Reduction p = 0.0036 Benefits of Enalapril Patients: Symptomatic HF patients with LVD (EF 35%) Increased Survival 32% at 3 months 28% at 6 months 21% at 12 months 18% at 24 months 12% at 36 months 12% at 48 months 11% reduction of overall mortality at end of study (P=0.0036) The SOLVD Investigators, N Engl J Med. 1991;325:293 SOLVD Treatment TrialMortality or Hospitalization for CHF N Engl J Med 1991;325:293-302 26% Risk Reduction p0.0001 SOLVD Treatment-Enalapril Symptomatic HF Patients with LVD (EF 35%) (NYHA Class II-III) Number of Hospitalizations Due to Heart failure The SOLVD Investigators, N Engl J Med, 1991 971 683 30% Reduction p0.001 SOLVD Treatment-Enalapril Symptomatic HF Patients with LVD (EF 35%) (NYHA Class II-III) Number of Readmissions for Heart failure The SOLVD Investigators, N Engl J Med, 1991 234 157 33% Reduction p0.001 SOLVD Treatment Trial Implications: Treating 1,000 patients for 3 years Prevents about 50 deaths Prevents about 350 hospitalizations The SOLVD Investigators, N Engl J Med. 1991;325:293 SOLVD Treatment Trial Conclusions Hospitalizations: Risk reduced by 20% (p0.001) Significant reduction in CHF hospitalization b