2015老年患者抗真菌治疗的安全用药重点.pptVIP

* 第一相反应包括氧化、还原、水解反应，第二相反应即结合反应 自消化道吸收的药物首先经过门脉系统进入肝，在肝脏被肝药酶转化或与组织成分结合，或随胆汁排出，最终导致进入体循环的药物明显减少，其减少的比例可用肝提取率（extraction ratio,ER)来描述： * * The warning concludes that… Micafungin treatment should be conducted on a careful risk/ benefit basis, particularly in patients having severe liver function impairment or chronic liver diseases.This warning is based upon pre-clinical animal data that threshold for heptaocellular tumours in rats. The EU reviewers were concerned because the threshold for tumour development in rats was approximately in the range of clinical exposure. * * 氟康唑、伏立康唑与CYP3A4、CYP2C9和C