2011重塑早相解析.pptVIP

首先第一点，从正常人与2型糖尿病患者的血糖峰值波动图不难发现：餐后血糖峰值是血糖波动的一个主要原因 。 第2点，餐后血糖波动幅度越大，氧化应激反应越严重 餐后高血糖导致氧化应激、炎性反应和内皮功能障碍 8-异前列腺素F2α是前列腺素F2α的异构体，被公认为氧化应激反应的标志物。 8-异前列腺素F2α清除率与平均血糖波动呈强正相关，表明血糖波动幅度越大，氧化应激越严重。 同时8-异前列腺素F2α清除率与空腹血浆胰岛素水平、HbA1c、空腹血糖和平均血糖浓度等日常测量指标无相关性。 When urinary excretion rates of 8-iso PGF2 were tested for simple linear correlations gainst markers of glucose control, the strongest correlation was found with MAGE (r=0.86; P.001) (FIGURE 2). A statistically significant correlation was also observedwithAUCpp(r=0.55;P=.009). In contrast, urinary excretion rates of 8-iso PGF2 did not correlate with fasting plasma insulin or with any of the parameters that are usually considered markers of mean glucose exposure, including HbA1c, fasting plasma glucose, and mean daily glucose concentrations The results of the present study show that the production of 8-iso PGF2 is higher in patients with type 2 diabetes than in healthy controls. Furthermore, acute glucose fluctuations were strongly correlated with urinary excretion of 8-iso PGF2, while no relationship was observed when urinary 8-iso PGF2 excretion rates were plotted against main markers of sustained hyperglycemia (HbA1c and mean daily glucose concentrations). 第3点，餐后高血糖导致脂质过氧化反应增加； 脂质过氧化反应主要是指在氧自由基诱发下发生生物膜不饱和脂肪酸中的一系列自由基反应,是氧自由基诱导的主要有害变化之一. 餐后2小时糖尿病患者脂质过氧化反应物显著高于其余两组，而餐后1小时糖尿病患者与IGT组无差异，餐后2小时较1小时高血糖更易导致炎性反应 脂质过氧化反应与血糖水平呈线性正相关，餐后血糖水平越高，炎性反应越重 第四点，餐后高血糖导致内皮功能障碍 血糖水平与动脉血流介导的舒张功能呈线性负相关，而血管舒张功能反应了血管内皮功能。餐后血糖越高，血管内皮功能受损越严重。 Technique for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery From: Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery Journal of the American College of Cardiology Volume 39, Issue 2, 16 January 2002, Pages 257-265 A report of the International Brachial Artery Reactivity Task Force Mary C. Corretti MD, FACC, Todd J. Anderson MD, Emelia J. Benjamin MD, MSc, David Celermajer MD, Francois Ch