HDL代谢的生理学和病理学意义PPT课件.pptVIP

HDL and Coronary Heart Disease Physiology and Pathophysiology of HDL Metabolism Structure of HDL Particle Production of HDL by Liver and Intestine HDL Metabolism and Reverse Cholesterol Transport Role of CETP in HDL Metabolism Role of Hepatic Lipase and Lipoprotein Lipase in HDL Metabolism Primary (Genetic) Causes of Low HDL-C ApoA-I Complete apoA-I deficiency ApoA-I mutations (eg, ApoA-IMilano) LCAT Complete LCAT deficiency Partial LCAT deficiency (fish-eye disease) ABC1 Tangier disease Homozygous Heterozygous Familial hypoalphalipoproteinemia (some families) Unknown genetic etiology Famil