HDL的药物治疗PPT课件.pptVIP

NCEP ATP-II Cutpoints for TG and HDL-C Parameter mg/dL Normal TG 200 Borderline-high TG 200–400 High TG 400–1,000 Very high TG 1,000 Low HDL-C 35 High (protective) HDL-C ? 60 Effects of Lipid-Modifying Drugs on HDL-C Levels Niacin ? 15–35% Fibrates ? 10–15% Estrogens ? 10–15% Statins ? 5–10% Drug Effects on HDL: Niacin Extended-Release Niacin for Treatment of Dyslipidemia Fibrate Chemical Structures Drug Effects on HDL: Fibrates Fenofibrate for Treatment of Types IV and V Hyperlipoproteinemia Trials of Agents That Increase HDL-C in Patients With Isolated Low HDL-CRandomized, Placeb