妇科尿毒症者血液中分子代谢物的清除和作用机制探讨.docVIP

妇科尿毒症者血液中分子代谢物的清除及作用机制探讨 [摘 要] 目的 为了探讨妇科尿毒症患者血液中分子代谢物清除方法及分子病理学机制。方法 回顾性总结我院收治妇科尿毒症患者44例资料，按照血液中中分子代谢物清除方法不同分为两组：单纯透析疗法的22例资料为对照组，在对照组治疗基础上加用血液透析串联血液灌流治疗的22例为观察组，术后按照文章疗效标准进行统计，最后讨论分子病理学机制。结果 观察组患者治疗后血液中中分子大小的代谢废物平均水平为（3182.4±344.5）U/L，明显低于治疗前的平均值（4108.3±530.5）U/L（P0.05），观察组患者治疗后临床症状改善情况（改善率86.4%）明显优于对照组统计结果（P0.05）。结论 妇科尿毒症患者及时通过血液透析串联血液灌流方法进行清除，对于维持机体生理功能的平衡具有重要的临床意义。 [关键词] 尿毒症，血液灌流，透析治疗 the molecular metabolites in blood of gynecological patients with uremia clearance method and molecular pathological mechanism [ABSTRACT] Objective To investigate the molecular blood metabolites in gynecological patients with uremia clearance method and molecular pathological mechanism. Methods retrospectively analysising 44 cases of uremic patients admitted to our hospital for gynecology, in accordance with the method of removing blood metabolites were divided into two groups: 22 cases of simple dialysis therapy for the control group, the control group treated with hemodialysis combined with hemoperfusion in the treatment of 22 cases of the observation group, postoperative according to the standard of curative effect statistics, finally discusses the molecular pathological mechanism. Results the patients in the observation group after treatment of waste products from the blood in the molecular size of the average of (3182.4 ± 344.5) U/L, were significantly lower than the average value of before treatment (4108.3 ± 530.5) U/L (P0.05), the patients in observation group after treatment, the clinical symptoms improved (improvement rate of 86.4%) significantly better than the control group (statistical results P0.05). Conclusion gynecological patients with uremia timely by hemoperfusion combined with hemodialysis methods are clear, and has important clinical significance for the maintenance of physiological functions of the body balance. [KEY WORDS] uremia, hemoperfusion, hemodialysis 尿毒症指急性或慢性肾功能不全发展到严重阶段时，由于代谢物蓄积和水、电解质和酸碱平衡紊乱以致内分泌功能失调而引起机体出现的一系列自体中毒症状[1-3]。妇科尿毒症，简单地说，就是人体不能通过肾脏产生尿液