进阶-0糖尿病的口服药物_20120712摘要.ppt

* One theoretical concern associated with insulin secretagogue therapy is the potential for beta-cell burnout. UKPDS 16 was reported after 6 years of follow-up and showed that intensive therapy was more effective in maintaining FPG and HbA1c levels than conventional therapy. However, the FPG increased progressively with all therapies (P0.0001) and beta-cell function declined regardless of treatment choice. A decline in insulin sensitivity was not observed. Overall, oral sulfonylurea therapy resulted in an initial improvement in beta-cell function. The subsequent decline in beta-cell function w