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AmmoniumDihydrogenPhosphateCatalystforOne-PotSynthesisof3,4-Dihydropyrimidin-2(1H)-ones.pdf

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AmmoniumDihydrogenPhosphateCatalystforOne-PotSynthesisof3,4-Dihydropyrimidin-2(1H)-ones.pdf

2012 Chinese Journal of Catalysis Vol. 33 No. 4 Article ID: 0253-9837(2012)04-0659-07 DOI: 10.1016/S1872-2067(11)60355-0 Article: 659–665 Ammonium Dihydrogen Phosphate Catalyst for One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones * Reza TAYEBEE , Behrooz MALEKI, Malihe GHADAMGAHI Department of Chemistry, School of Sciences, Hakim Sabzevari University, Sabzevar 96179-76487, Iran Abstract: A one-pot three component Biginelli condensation of different substituted aromatic and aliphatic aldehydes with ethyl acetoace- tate and urea to the respective 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions that is simple, effective, and environmentally friendly was shown. Ammonium dihydrogen phosphate (NH H PO ) was used as a non-toxic, inexpensive, and easily available catalyst. The 4 2 4 facile reaction condition and simple isolation and purification procedures of this method make it a good option for the synthesis of dihydro- pyrimidinones. Key words: 3,4-dihydropyrimidin-2-(1H)-one; ammonium dihydrogen phosphate; solvent free; condensation CLC number: O643 Document code: A Received 12 October 2011. Accepted 18 December 2011. *Corresponding author. Tel: +98-571-4410310; Fax: +98-571-4410300; E-mail: rtayebee@ This work was partially supported by the Research Council of Hakim Sabzevari University. English edition available online at Elsevier ScienceDirect (/science/journal. 3,4-Dihydropyrimidin-2(1H)-ones have a wide range of phosphoric acids [11], inorganic solid acids such as zeolite therapeutic and pharmacol