n-(2-羟基乙基)芥酰胺对高脂血症金黄地鼠的降脂及其保肝作用.pdfVIP

1252 药学学报 Acta Pharmaceutica Sinica 20 12, 47 (9): 1252 1256 · 究简报· N -(2- 羟基乙基) 芥酰胺对高脂血症金黄地鼠的降脂及保肝作用 * * 沈燕慧, 金 鑫, 赵 云, 古丽米然·阿里同别克, 林丽敏, 舒 萍, 魏 晓 (厦门大学医学院, 福建 厦门 361005) 关键词: N-(2-羟基乙基) 芥酰胺; 高脂血症; 脂肪肝; 金黄地鼠 中图分类号: R965 文献标识码: A 文章编号: 05 13-4870 (20 12) 09- 1252-05 The hypolipidemic and liver protective effect of (Z)-N-(2-hydroxyethyl) docos-13-enamide on hyperlipidemic golden hamsters * * SHEN Yan-hui, JIN Xin , ZHAO Yun , ALtunbak GuLmira, LIN Li-min, SHU Ping, WEI Xiao (College of Medicine, X iamen University, X iamen 361005, China) Abstract: This study is to observe preventive effect of (Z)-N -(2-hydroxyethyl) docos- 13-enamide on hyperlipidemia and fatty liver of golden hamsters. Hyperlipidemic golden hamsters fed with high-fat diet 1 was administered orally with (Z)-N -(2-hydroxyethyl) docos- 13-enamide ( 10, 20 and 40 mg ·kg ) for 5 weeks. Levels of serum and hepatic lipid content, liver histology, hepatic MDA and SOD levels, serum ALT and AST levels were evaluated in golden hamsters. (Z)-N -(2-Hydroxyethyl) docos-13-enamide has a hypolipidemic effect, and could reduce hepatic lipid content, serum ALT and AST levels, hepatic MDA level, increase hepatic SOD activity. (Z)-N -(2-Hydroxyethyl) docos- 13-enamide plays an important role in reducing serum lipid, restraining hepatic fatty deposition and protecting liver to get rid of peroxidation inj ury of hyperlipidemic golden hamsters. The exact