益气健脾法治疗脾虚型2型糖尿病的临床疗效观察及作用机理探讨_论文.docVIP

Clinical Observation and Mechanism of Spleen Qi Treatment of Spleen Deficiency Type 2 Diabetes Speciality: Internal medicine of traditional Chinese Medicine Author:Zhou Liangjun Tutor:Prof.Sun Fenglei Abstract Objective: Through clinical research, clinical efficacy of hypoglycemic side treatment of observed spleen and spleen deficiency type 2 diabetes. Through animal studies, observation of the Spleen Qi classic recipe (Four Junzi Decoction) Spleen Deficiency Syndrome blood glucose, pancreatic glucagon-like peptide-1 (GLP-1), insulin, glucagon, gastrin, suppresses stomach peptides, and other indicators, and to explore the mechanism of diabetes spleen. Methods:Clinical observation: meet the inclusion criteria, 60 cases of type 2 diabetes were randomly divided into experimental group and control group, 30 cases in each group. The two groups were given diet, exercise, hypoglycemic and western medicine treatment, the test group were treated with the spleen hypoglycemic side, a decoction day, 2 times service. 8 weeks after treatment, the clinical syndrome points, fasting glucose, 2-hour postprandial blood glucose, glycosylated hemoglobin, fasting insulin and other indicators for evaluating the content, the development of efficacy standards, compared with the control group. (2) Animal experiments: divided into normal group, model group, treatment group three groups. Spleen deficiency type 2 diabetes animal model, after the model was successful, the treatment group to continue to give the four gentleman Tangnong decoction orally 10 days, the normal group and model group was given an equal volume of distilled water. Determination of blood glucose after injection of GLP-1, insulin, glucagon, gastrin, gastric inhibitory peptide and other indicators. Results: Spleen hypoglycemic effective in order to improve type 2 diabetes, fasting glucose, 2-hour postprandial blood glucose, glycosylated hemoglobin, fasting insulin and other indicators were significant differences (P 0.05) c