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* Key Point Champix? (伐尼克兰 ) was deliberately designed for the ?4?2 receptor, as an ?4?2 nicotinic receptor partial agonist (with dual agonist and antagonist properties) and physically prevents nicotine from binding as an aid in smoking cessation Background: The initial view of the mesolimbic system identifies the VTA where the ?4?2 receptors predominate, as well as the nAcc. The release of dopamine at the nAcc from the axons of the dopamine cells of the VTA is believed to produce a reward response. When nicotine binds at the ?4?2 nicotinic receptor in the VTA, it is believed to cause release of dopamine at the nAcc. Champix? (伐尼克兰 ) was deliberately designed for the ?4?2 receptor, as an ?4?2 nicotinic receptor partial agonist (with dual agonist and antagonist properties) and physically prevents nicotine from binding and releases intrinsically less dopamine at the nAcc. References Coe JW, Brooks PR, Wirtz MC et al. 伐尼克兰 (CP-526, 555): A novel, potent, and selective nicotinic receptor partial agonist for the treatment of smoking cessation: Rationale, discovery, and mode of action. Presented at the 11th Annual Meeting and 7th European Conference of the Society for Research on Nicotine and Tobacco, March 20–23, 2005, Prague, Czech Republic. Picciotto MR, Zoli M, Changeux J. Use of knock-out mice to determine the molecular basis for the actions of nicotine. Nicotine Tob Res. 1999;Suppl 2:S121-S125. * Key Point 伐尼克兰 is indicated for smoking cessation in adults Background: 伐尼克兰 is indicated for smoking cessation in adults. When prescribing 伐尼克兰 , physicians also should provide patients with advice and support concerning their attempt at quitting smoking, as smoking cessation therapies appear to be more likely to be successful in conjunction with behavioral interventions. Patients must choose a date to quit smoking and initiate 伐尼克兰 treatment 1-2 weeks before this date. 伐尼克兰 should be taken with a full glass of water, with or without food, with titr