西沙必利联合埃索美拉唑、奥美拉唑治疗反流性食管炎的临床比较.docVIP

西沙必利联合埃索美拉唑、奥美拉唑治疗反流性食管炎的临床比较 　　[摘要] 目的 探讨西沙必利联合埃索美拉唑、奥美拉唑治疗反流性食管炎的疗效和安全性。 方法 随机选取该院2013年3月―2014年5月间收治的反流性食管炎80例患者，作为研究对象，随机分为两组，对照组40例采用西沙必利联合奥美拉挫进行治疗，研究组40例采用埃索美拉唑联合西沙必利治疗，对两组的疗效及安全性进行比较。 结果 研究组患者治疗总有效率为95%，明显高于对照组75%的治疗总有效率，研究组的不良反应发生率显著低于对照组，数据比较差异有统计学意义（P中国论文网 /6/view-7244003.htm 　　[关键词] 西沙必利；埃索美拉唑；奥美拉唑；反流性食管炎 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2016）02（a）-0148-02 　　Clinical Comparison of Cisapride Combined with Esomeprazole and Cisapride Combined with Omeprazole in Treatment of Reflux Esophagitis. 　　WANG Jian-jun 　　Department of gastroenterology， Jiaozuo Second People’s Hospital， Jiaozuo， Henan Province， 454000 China 　　[Abstract] Objective To discuss the curative effect and security of cisapride combined with esomeprazole and cisapride combined with omeprazole in treatment of reflux esophagitis. Methods 80 cases of patients with reflux esophagitis treated in our hospital from March 2013 to May 2014 were selected as the research object and randomly divided into two groups with 40 cases in each， the control group were treated with cisapride combined with omeprazole， the research group were treated with cisapride combined with esomeprazole， the curative effect and security of the two groups were compared. Results The total treatment effective rate in the research group was obviously higher than that in the control group （95% vs 75%）， the incidence of adverse reaction in the research group was obviously lower than that in the control group， and the difference was statistically significant by comparison P0.05），具有可比性。 　　1.2 方法 　　对所有病例进行基础药物治疗，对照组空腹口服40 mg奥美拉挫（肠溶胶囊剂，规格20 mg×14粒/瓶，悦康药业集团有限公司，批准文号国药准字，饭前30 min服用5 mg西沙必利（片剂，规格5 mg×10 s，海南三叶制药厂有限公司，国药准字：，3次/d；研究组空腹口服40 mg埃索美拉唑美肠溶片（片剂，规格20 mg×7 s，阿斯利康制药有限公司，国药准字，饭前30 min服用5 mg西沙必利，3次/d。4周为1个疗程，在用药1个疗程后复检。 　　1.3 疗效指标 　　临床疗效的评估标准。愈合：烧心、疼痛、泛酸、腹胀及恶心等症状消失，胃镜下溃疡完全愈合；有效：烧心、疼痛、泛酸、腹胀及恶心等症状有所好转，溃疡数量降低50%以上，或者溃疡面积缩小50%以上；无效：烧心、疼痛、泛酸、腹胀及恶心等症状未改变甚至加重，溃疡愈合小于50%或者无变化甚至溃疡数量、面积增加。总有效率=（愈合+有效）/患者