CVC与真菌生物被膜_重点分析.ppt

As can be seen in Fig. ?Fig.4D,4D, the level of ergosterol decreased by 41% between early- (6 h) and intermediate (12 h)-phase biofilms (Fig. ?(Fig.4D;4D; P 0.001). Moreover, ergosterol level was reduced by 50% at mature phase, compared to that for early-phase biofilms (Fig. ?(Fig.4D;4D; P 0.001). 生物被膜与浮游白念珠菌麦角固醇水平在6h时相同，生物膜成熟期减少50%，而浮游细胞在6～12h减少18%，其他固醇水平在两者之间也有明显差异 表明生物膜固醇结合物在与唑类相关的生物膜耐药性的中晚期起重要作用 It is possible that there exists a threshold level of ergosterol that contributes to resistance. Changes in sterol profile may lead to altered membrane permeability and hence prevent or retard