IGA分子遗传学进展介绍.docVIP

IgA肾病分子遗传学研究新进展 Advances in molecular genetics research of IgA nephropathy Abstract: IgA nephropathy IgAN , which can develop into end-stage renal disease, is the most common primary glomerulonephritis. The pathogenesis of IgAN is not clear, many studies have confirmed that genetic susceptibility is associated with IgAN, and it belongs to polygenic disease. Some studies have found that IgAN was associated with chromosome 6q22-23, 2q36 by linkage analysis, and several candidate genes were confirmed by association study to be associated with IgAN, such as ACE、FCAR、HLA. In recent years, as the p