调节性B细胞原发性干燥综合征发病机制探讨.pdf

后组(4．62士3．1 1％，p=0．004)。有眼干症状患者Breg细胞占淋巴细胞百分比 (1．634-1．31％，p=0．045)。 强度(po．038)较初治组均降低。 成正相关。 度与C3(po．030，R=0．462)正相关。 比升高，培养上清中也．10浓度降低，IFN-?浓度降低。 4 【结论】 清IgG呈正相关；初治组Breg淋巴细胞百分比较免疫抑制组高，推测pSS外周血 能在pSS中起抑制过度自身免疫反应的作用。 【关键词】 受体(BAFF．R) 5 Abstract a sj69ren’Ssyndrome(pSS)is Background．Primary diseaseinwhich activated B asone autoimmune abnormallyanddifferentiatedcellsact B Bcell ofthemost are defined importantcharacteristics．Regulatorycells(Brednewly wiⅡl functions．Torolesfor cellshave immunosuppressive Breg subgroups date，key beenidentifiedinthe ofseveral immune-mediated regulation processes，including and toinfectiousdiseaseand autoimmunityresponses CanCer．Ithasbeendemonstrated thathuman CD19+CD24hiCD38KBcells functionand peripheral possessedregulatory thatCD1 cells be arestillfew 9+CD5+Foxp3+BmaypotentialBreg．However,there researchesonhow functionsin anditsrelevancewitlldiseaseactivitiesand Breg pSS features．Inthis tricdto differences in clinical research,we the Breg investigate among 19十B andBAFF andCD of cells，the CD69，CD80 receptor lymphocytes expression