药学英语.pptVIP

注射用奥美拉唑说明书 【 药品名称 】 注射用奥美拉唑钠 【 药品别名 】Ingredients: Omeprazole 奥克? 本品主要成份为：奥美拉唑钠，其化学名称为：5-甲氧基-2-｛[(4-甲氧基-3, 5-二甲基-2-吡啶基)-甲基]-亚磺酰基｝-1H-苯并咪唑钠盐一水合物。 Ingredients: Omeprazole Sodium, whose chemical name is 5-methoxy-2-{[4-methoxy-3, 5-dimethyl-2-pyridyl-methyl]-sulphony}-1H-benzimidazolesodrum salt-Hydrate Molecular Formula: C17H18N3NaO3S-H2O Molecular Weight: 385.41 【 药代动力学 】[Pharmacokinetics] 静脉注射本品后，体内分布在肝、肾、胃、十二指肠、甲状腺等组织，分布容积为0.19～0.48L/kg，与细胞外液体积相当。T1/2为0.5～1小时，慢性肝病患者为3小时。本品主要在肝脏中经细胞色素P450代谢，代谢产物主要为硫醚、砜和羟基衍生物。对胃酸的分泌无作用，代谢完全，仅少数以原形排泄。约有80%的代谢物经肾排出，部分（18～23%）随粪便排出。有肠肝循环过程，血浆蛋白结合率高，达95%左右。肾衰患者对本品的清除无明显变化，肝功能受损者清除半衰期可有延长。 When injected intravenously, the drug is distributed among the tissues of liver, kidney, stomach, duodenum and thyroid gland with its distribution volume at 0.19-0.48 L/Kg, equivalent to the volume of extracelluar fluid. Its half life is 0.5-1 hour and 3 hours for chronic hepatopath. Most of its metabolic processes take place in the liver by cytochrome P450. its metabolites are mainly thioether, salphone and hydroxyl derivate, which have no effect on the secretion of gastric acid and its complete metabolism eaves very small percentage of the drug excreted in its original shape. About 80% of metabolites are excreted by kidney while another 18%~20% along with feces. It has high affinity rate for plasma protein which reaches 95% and enterohepatic circulation. There is no evident change in drug elimination for patients with renal failure while the half-life of elimination may be prolonged for the patients who are suffering from impairment of liver function. 【 适应症 】[Indication] 主要用于：(1)消化性溃疡出血、吻合口溃疡出血。(2)应激状态时并发的急性胃黏膜损害，和非甾体类抗炎药引起的急性胃黏膜损伤；(3)亦常用于预防重症疾病（如脑出血、严重创伤等）胃手术后预防再出血等；(4)全身麻醉或大手术后以及衰弱昏迷患者防止胃酸反流合并吸入性肺炎。 1. hemorrhage of peptic ulcer and marginal ulcer 2. Impairment of acute gastric mucous membrane complicated in the stress state, or triggered by non-steroids anti-inflammatory agents. 3. Prevention of rehemorrhage after operation for glare disease, e.g