贵阳代谢记忆剖析.pptVIP

尽早控制 尽快达标 持久稳定 目前对血糖控制的观念 * * * 细胞内高血糖诱导线粒体过量产生超氧化物，这是糖尿病并发症发病机制的第一步也是最重要的一步，随后激活多元醇通路和氨基己糖通路，AGEs形成增多，蛋白激酶C和NF-γB的激活。在高血糖环境中线粒体蛋白糖基化，诱导线粒体产生过量超负氧离子。在这种情况下，即使高血糖得到纠正，糖化的线粒体继续产生过量超负氧离子，活化上述与糖尿病并发症发生有关的通路。 * Studies have shown that good metabolic control (GC) is beneficial in slowing the progression of nephropathy in diabetes, and if the duration of poor metabolic control (PC) is prolonged before reinstitution of GC, nephropathy is not easily reversed. This study is to identify the biochemical abnormalities that could contribute to the resistance of nephropathy to reverse after establishmen