表观遗传学回顾解说.ppt

DNA修复和染色质修饰 组蛋白内作用因子,也被称为chromatin-assembly因素(CAF),能可优先结合组蛋白亚序列。 染色质DNA复制时chromatin-assembly因子1(CAF1),可以优先结合乙酰化H3和H4,。CAF-1还会促进染色质DNA修复和装配。 研究技术 染色质免疫共沉淀与ChIP-on-chip和ChIP-seq结合, 荧光原位杂交 DNA腺嘌呤甲基化酶鉴定和 (DamID) 和亚硫酸氢盐浰序。 生物信息学方法发挥着越来越大的作用(计算表观遗传学)。 * 进行性肺病 * 王牌大贱牒2 In lymphoid organs endothelial cells express oligs recognised by L-selectin on lymphocytes, causing them to loiter At inflammation sites endothelial cells express selectins to catch white blood cells and platelets Collaboration with integrins Some proteoglycans secreted as mucus, etc. Apical = outside (e.g. facing gut) Tryp. uses phos