AsthmaImmunePhenotypes哮喘免疫表型剖析.ppt

* Figure 1. Interleukin-13 and Non–Interleukin-13 Inflammatory Pathways in Asthma.?Inhaled allergen activates mast cells, which are maintained by stem-cell factor (SCF) produced by epithelial cells and by dendritic cells, through cross-linking with IgE on their cell surfaces via FcεR1 to release mediators that induce bronchoconstriction, such as histamine, cysteinyl leukotrienes, and prostaglandin D2 (PGD2). Allergens are processed by dendritic cells, which are induced to secrete the CC chemokine ligand (CCL) 17 and CCL22 by thymic stromal lymphopoietin (TSLP). Dendritic cells then attract and