大鼠初级视皮层的集群响应特征提取.docVIP

摘要 视觉系统是人类和动物体进行信息处理、传递、加工和存储的主要系统。研究已经证明，外界信息的80%都是由视觉神经系统接受并且处理的。而几乎所有的外界刺激信息都要经过初级视皮层的V1区进行初步整合后才传输给高级皮层进一步认知。越来越多的研究证明其对视觉刺激信息的编码是由神经元集群协同完成的。因此，从集群的角度来研究V1区的神经元对视觉刺激信息的编码机制对解析视觉系统的信息处理机制具有非常重要的意义。 本文采用大鼠作为实验对象，以全屏光栅为刺激模式，采用微电极阵列采集技术采集放电信号，然后对采集到的神经元信号进行相关性分析，并对其相关性进行了特征提取。内容如下： 设计实验方案，进行实验。用不同朝向的移动光栅作为刺激模式，采用微电极阵列采集神经元信号。并对采集到的信号进行预处理，得到单一神经元的有效响应信号。 对神经元有效响应信号进行时域和频域的相关性分析。在时域和频域中分别对信号刺激前后以及不同朝向时的相关性进了了分析，并进行特征提取。得出神经元之间的冗余性在刺激前比较大，刺激后神经元之间更加独立。 初级视皮层，锋电位，相关性，特征提取 Abstract The visual system of human beings and animals is the main system of information processing, transmission and storage. Studies have shown that 80% of the information from the outside world is accepted and processed by the visual system. Before transmitted to higher cortical cognition, almost all of the information from external stimulation needs the primary visual cortex V1 area to do the initial integration. More and more studies have shown that the code of visual stimulation information is completed by the cooperative clusters of neurons. Therefore, the study of how the V1 area encodes the visual stimulus information from the perspective of cluster is of very important significance for analyzing the information processing mechanisms of the visual system. In this paper, rats are used as experimental subjects. Then the V1 area of the primary visual cortex of the rats is studied and microelectrode array is adopted to obtain the neuron signals through the stimuli of full screen crating. Finally, the correlation of the action potential of these signals is analyzed. The items are as follows: The experiment is designed and conducted. By using full-screen grating as stimulus mode and the microelectrode array as collecting device, neurons signals are acquired and then pre-processed. Finally, the effective response signal of single neuron is got. The correlation between the time domain and the frequency domain of the effective response signals is analyzed. Next, the interaction between neurons is