流式细胞术检测急性白血病完全缓解微小残留病和临床意义.pdfVIP

浙汀人学帧Ij学f奠论义 中文摘要 平均跟踪随访6个月(3个月一25个月)，得出完全缓解病人MRD平均值，并对其 在评估CR患者预后中的价值进行分析和总结． 研究结果：所统计的51例ALL患者，测得完全缓解时B．ALL最大检测值为8．83％， 复发25例，均可见MRD0．1％时复发率明显升高。 结论．o FCM监测急性白血病MRD检测值差异较大，10。5～10～，不能作为评价完全 缓解的单一指标。MRD可以作为预后评价的敏感指标，MRD_0．1％提示复发可 能性大。当MRD≥1％时，提示可能在3月内复发。 关键词：微小残留病，急性自血病，完全缓解，复发 浙江人学顺lj学位论迁 英史摘要 Minimalresidual disease ofacuteleukemiawith monitoring ’ ● ● o● ● ‘一 remISSionandits Aecncompleteacilin21s Abstract remissionofacuteleukemiais：clinical and Background：Complete symptomssigns blood levelofblastcellsinthebonemarrowislessthan disappeared；normalimage，the arelotsof1eukemiccellsstillexisted 5％．However,there whichcouldnotbedetected conventional iscalledminimal by microscopy．It residual residual disease(minimal isthecourseof an factorand disease，MRD)．MRDrelapse．Asindependentprognostic ofcriteriaof MRD the levelofleukemiatothe part CIL promotesmorphology molecularlevel．Itis tomonitor ofMRD clinical important quantification during remission period． observethe MRD objectives：Tolevelof inacuteleukemia with patientscomplete remissionand therole MRDin andits explore ofmonitoringrelapse significance． Methods：Acuteleukemia 1 casesofadultacute