《Recent advances of electrochemical mass spectrometry》.ppt

Help to ionize species that are not easily protonated or deprotonated Cause acidication of the sample solution that flows through an ESI source Removal of interfering metal ions from the sample solution via reduction deposition or to oxidize metals deposited on the ESI emitter for qualitative and even quantitative analyses ionize aqueous samples directly without addition of organic additives high salt tolerance inherent conflict between the small potential applied to the EC cell and the high voltage used for spray ionization is avoided in EC/DESI-MS simple instrumentation and fast response time Electrochemical mass spectrometry has recently experienced many exciting developments, mainly due to the advances of microfluidics techniques and the advent of ambient mass spectrometry. With further innovation in instrumentation, it is anticipated that the combined electrochemistry and mass spectrometry method would be more versatile and powerful in tackling challenges in modern analytical and bioanalytical chemistry. Conclusions * * * * Reporter:Hongbin Zou The Literature Report Date：2015-1-19 Author: Pengyuan Liu Mei Lu Qiuling Zheng Yun Zhang Howard D. Dewald Hao Chen* Recent advances of electrochemical mass spectrometry [Analyst, 2013, 138, 5519] Pengyuan Liu Hao Chen Fig.1 Timelines for the development of EC/MS and ionization methods. EC/MS Fig.2 Schematic showing the ESI process. EC/ESI-MS Applications of inherent electrolysis in ESI Fig.3 ESI-MS spectra of 5mM reserpine obtained using a porous flow through(PFT) electrode emitter with a spray voltage of 5kV applied in (a)DC mode and (b)as 100Hz 10ms pulses.Note that reserpine was oxidized to its 2, 4, 6 and 8-electron oxidation products (m/z 625, 623, 621 and 619, respectively) in (a) when direct current high voltage was employed. Fig.4 Different configurations of EC/ESI-MS apparatus involving (a)a tubular electrochemical cell (b)a thinlayer electrochemical flow cell and (c) a built-in electrochemical cell.