RhoAROCK信号通路在心肌肥厚与心力衰竭中的作用及法舒地尔的干预效应.pdf

lIII I III IIIUIIII I II 138 ＼1901 目 录 中文摘要………………………………………………………………………………．．1 英文摘要……………………………………………………………………………．．11 英文缩写…………………………………………………………………………26 研究论文 RhoA瓜OCK信号通路在心肌肥厚和心力衰竭中的作用及 法舒地尔的干预效应 引言……………………………………………………………………………………………28‘j7l百．．．．…．．．…．．………．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．么5 PARTONERhoA／ROCKan rolein may playimportant cardiomyopathy INTRODUCTION………………………………………………………………………．．30 NLATEIUALSAND METHODS……………………………………………………．3l l也SULTS……………………………………………………………………………………43 FIGURES……………………………………………………………………………………．46 TABLES………………………………………………………………………………………53 DISCUSSION．．．．…．．．．．．．．．．．．．．．．．．…．．．．．．．．．．．．．．．．…．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．55 CONCLUSIONS…………………………………………………………………………．59 REFERENCES……………………………………………………………………………．59 PARTTⅥ℃ R_hoA依OCKmediates heartfailure in isoproteren01．induced rats via胍andERK1／2pathways INTRODUCTION………………………………………………………………………．．66 MEIUALSANDMETHODS……………………………………………………．67 RESULTS……………………………………………………………………………………79 FIGI 7RES……………………………………………………………………………………．84 TABLES………………………………………………………………………………………92 DISCUSSIO】!叮．．．．…．．．．．．．．．．．．．．．．．．．．．．．．…．．．．．．．．．．…．．．．．．．…．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．94 CONCLUSIONS…………………………………………………………………………．97 REFERENCES……………………………………………………………………………．98 PARTTHREERhoA／ROCKinvolveincardiac induced may