无线控制脑电波刺激器设计.docVIP

无线脑电波刺激器的设计 摘要 长期以来，药物成瘾带来了严重的社会问题，寻找一种有效的“戒瘾”手段也成为医学界研究的重要课题。目前，治疗药物成瘾的方式主要为两种：药物治疗和非药物治疗。两种方法具有一定的疗效，但都存在着一些不足，应用上受到一定限制。随着脑深部电刺激器(deep brain stimulation，DBS)在运动障碍性疾病、癫痈、疼痛、精神疾病等外科治疗中的成功应用，DBS在手术戒毒治疗中的应用议题引起了学界的广泛关注。 脑深部电刺激技术具有对脑结构损伤小、并发症少、可逆等优点，然而，该技术在药物成瘾治疗中的应用仍处于实验研究阶段，为了支撑该技术在药物成瘾治疗中的实验研究，满足众多患者临床应用的强烈需求，研究设计一套可靠性高的脑深部电刺激系统也显得尤为重要。 本文在查阅大量文献的基础上，分析总结了脑深部电刺激技术治疗药物成瘾的机理及发展现状;根据脑深部电刺激器的组成结构及工作原理，深入研究了DBS设计的各项关键技术，包括供电技术、通信技术、系统控制技术等。结合DBS微型化、低功耗的设计要求，提出了一种基于无线控制技术的DBS设计方案，并详细论述了方案的可行性。为满足数据通信稳定可靠的需要，设计采用低功耗短距离射频通信技术实现DBS系统的数据传输。 整个DBS系统分为体外控制器和体内刺激器两大部分，论文重点分析研究体内刺激器的设计方法。根据体内刺激器设计指标，采用单片机STC10L08XE、低功耗短距离射频通信模块nRF24L01、双运放大电路实现压控恒流输出刺激信号的体内刺激系统的软硬件设计，并进行了相应的刺激脉冲输出、通信质量、功耗等功能测试分析。实验结果表明，刺激脉冲可调恒流输出，数据通信稳定可靠，满足设计要求。 关键词：DBS，药物成瘾，无线控制 Research on the Wireless Control Deep Brain Stimulation (DBS) Technology Abstract:Drug addiction has become a big social problem for a long history.To find an effective solution for the drug addiction therapy has become an important research topic. Now, there are mainly two solutions for the drug addiction therapy: medicine therapy and non-medicine therapy. Both solutions were proved to be effective, but they are not so popular for the clinical applications because of some drawbacks. As a quite promising technique which has been already widely applied in the fiel7ds like physical disabled disease, falling sickness, psychoses, et al., DBS is a hot research topic for the applications in the surgery on the drug addiction. It has already been proved that DBS technique has much less brain destruction and much less syndrome and is reversible. But the application of this technique on the drug addiction therapy is still far from the clinical application. A lot of related research work is still in progress. To support the experimental research requirements on drug addiction therapy and to satisfy the clinical application, it is quite important to design a high reliability DBS system. Based on the collected documents, the principle and the deve