以FcγR为靶标治疗炎症及癌症的药物研究状况.doc

 PAGE \* MERGEFORMAT 3 以FcγR为靶标治疗炎症及癌症的研究概况 2012-12目 录  TOC \o 1-3 \h \z \u  HYPERLINK \l _Toc343679748 第一章 概述FcγR与IgG的结构与功能  PAGEREF _Toc343679748 \h 1  HYPERLINK \l _Toc343679749 第三章 可溶性FcγR  PAGEREF _Toc343679749 \h 7  HYPERLINK \l _Toc343679750 第四章 抗FcγR的单抗  PAGEREF _Toc343679750 \h 11  HYPERLINK \l _Toc343679751 第五章 小分子肽和类肽物  PAGEREF _Toc343679751 \h 13  HYPERLINK \l _Toc343679752 第六章 免疫球蛋白类似物  PAGEREF _Toc343679752 \h 17  HYPERLINK \l _Toc343679753 第七章 小分子化合物  PAGEREF _Toc343679753 \h 19  HYPERLINK \l _Toc343679754 第八章 静脉注射免疫球蛋白  PAGEREF _Toc343679754 \h 22  HYPERLINK \l _Toc343679755 第九章 修饰Ig的Fc段  PAGEREF _Toc343679755 \h 28  HYPERLINK \l _Toc343679756 第十章 修饰IgG的半衰期  PAGEREF _Toc343679756 \h 36  HYPERLINK \l _Toc343679757 附件1 Fc/FcR的化学计量学问题  PAGEREF _Toc343679757 \h 45  HYPERLINK \l _Toc343679758 附件2 FcγR与IgG结合的空间构象  PAGEREF _Toc343679758 \h 47   PAGE \* MERGEFORMAT 50 第一章 概述FcγR与IgG的结构与功能 一、FcγR在体内不同细胞上的分布与表达水平 ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l _ENREF_1 \o Hogarth, 2012 #1617 1,  HYPERLINK \l _ENREF_2 \o Hulett, 1994 #1618 2] FcγRs are the most diverse family of FcRs and include three distinct classes of receptor encoded by six genes: FCGR1A (which encodes FcγRI; also known as CD64), FCGR2A (which encodes FcγRIIa; also known as CD32A), FCGR2B (which encodes FcγRIIb; also known as CD32B), FCGR2C (which encodes FcγRIIc; also known as CD32C), FCGR3A (which encodes FcγRIIIa; also known as CD16A) and FCGR3B (which encodes FcγRIIIb; also known as CD16B). FCGR2C is the product of a crossover between FCGR2A and FCGR2B, which share a high degree of homology. 二、FcγR的分型与结构 ADDIN EN.CITE  ADDIN EN.CITE.DATA [ HYPERLINK \l _ENREF_1 \o Hogarth, 2012 #1617 1-3] The Fc receptors (FcRs) consist of an immunoglobulin-binding polypeptide chain containing two immunoglobulin-like domains that form the extracellular region. FcγRI is an exception