Biotransformation Metabolism of Drugs课件.pptVIP

Biotransformation (Metabolism) of Drugs ;General properties ;Results of biotransformation;;Biotransformation of drugs can be affected by many parameters, including: prior administration of the drug in question or of other drugs diet hormonal status genetics disease (e.g., decreased in cardiac and pulmonary disease) age and developmental status liver function;;;Classification of biotransformation reactions;;Drug metabolism reactions : ;Enzymes catalyzing phase I biotransformation reactions;Enzymes catalyzing phase II biotransformation reactions include: glucuronyl transferase (glucuronide